Objectivists and others often criticize Martin Luther for his attacks on reason. (There is a quote from Luther heading Douglas Rasmussen's articles in the lastest issue of JARS.) Luther is known, for example, for referring to "that whore reason." One thing to consider about Luther is that he had a peasant's sense of humor and exaggeration, which explains some of his outrageous statements.
Some of Luther's diatribes at reason were directed at what he felt was an over-confident Scholastic belief in reason. This is discussed in R.C. Sproul's book Classical Apologetics.
Here is an article that discusses Luther's view of science.